Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.
Identifieur interne : 004936 ( Main/Exploration ); précédent : 004935; suivant : 004937Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.
Auteurs : Anjeanette Roberts [États-Unis] ; Christopher Paddock ; Leatrice Vogel ; Emily Butler ; Sherif Zaki ; Kanta SubbaraoSource :
- Journal of virology [ 0022-538X ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Facteurs de l'âge, Modèles animaux de maladie humaine, Pneumopathie infectieuse (anatomopathologie), Souris, Souris de lignée BALB C, Susceptibilité à une maladie, Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS, Évolution de la maladie.
- MESH :
- anatomopathologie : Pneumopathie infectieuse.
- diagnostic : Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Facteurs de l'âge, Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C, Susceptibilité à une maladie, Virus du SRAS, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Severe Acute Respiratory Syndrome.
- pathology : Pneumonia.
- virology : Severe Acute Respiratory Syndrome.
- Age Factors, Animals, Disease Models, Animal, Disease Progression, Disease Susceptibility, Mice, Mice, Inbred BALB C, SARS Virus.
Abstract
Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.
DOI: 10.1128/JVI.79.9.5833-5838.2005
PubMed: 15827197
Affiliations:
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SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Butler, Emily" sort="Butler, Emily" uniqKey="Butler E" first="Emily" last="Butler">Emily Butler</name><name sortKey="Paddock, Christopher" sort="Paddock, Christopher" uniqKey="Paddock C" first="Christopher" last="Paddock">Christopher Paddock</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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